CORTICOTROPIN-RELEASE INHIBITORY FACTOR - EVIDENCE FOR DUAL STIMULATORY AND INHIBITORY HYPOTHALAMIC REGULATION OVER ADRENOCORTICOTROPIN SECRETION AND BIOSYNTHESIS

被引：12

作者：

ENGLER, D ^{[1
]}

LIU, JP ^{[1
]}

CLARKE, IJ ^{[1
]}

FUNDER, JW ^{[1
]}

机构：

[1] MONASH MED CTR,MOLEC EMBRYOL & BIRTH DEFECTS LAB,CLAYTON,VIC 3168,AUSTRALIA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/1043-2760(94)P3202-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypothalamus is currently thought to stimulate the synthesis and secretion of ACTH uniquely by secreting neuropeptides into the hypophysial-portal circulation of which the most important ave CRH and arginine vasopressin. However analysis of the effects of pituitary isolation on the pituitary-adrenal axis in a variety of species suggests that the hypothalamus exerts both stimulatory and inhibitory regulation over ACTH secretion and POMC biosynthesis, and that ate inhibitory control is dominant. Because none of the currently known inhibitory factors in the hypophysial-portal circulation consistently decreases basal ACTH secretion and POMC mRNA levels in normal anterior pituitary cells, if is suggested that this inhibition is mediated by a currently unidentified hypothalamic substance, presumably a neuropeptide, which we have termed corticotropin-release inhibitory factor (CRIF). The possible roles in clinical medicine of agonists and antagonists of this putative CRIF ave discussed.

引用

页码：272 / 283

页数：12

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