STRUCTURAL EVIDENCE FOR GENE DUPLICATION IN EVOLUTION OF ACID PROTEASES

被引：365

作者：

TANG, J

JAMES, MNG

HSU, IN

JENKINS, JA

BLUNDELL, TL

机构：

[1] UNIV ALBERTA,DEPT BIOCHEM,MRC,PROT STRUCT & FUNCT GRP,EDMONTON T6G 2H7,ALBERTA,CANADA

[2] UNIV LONDON,BIRKBECK COLL,DEPT CRYSTALLOG,MOLEC BIOL LAB,LONDON WC1,ENGLAND

来源：

NATURE | 1978年 / 271卷 / 5646期

关键词：

D O I：

10.1038/271618a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular two-fold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented. © 1978 Nature Publishing Group.

引用

页码：618 / 621

页数：4

共 27 条

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