CYTOLOGICAL AND IMMUNOLOGICAL RESPONSES TO BABESIA-DIVERGENS IN DIFFERENT HOSTS - OX, GERBIL, MAN

被引：93

作者：

GORENFLOT, A

BRASSEUR, P

PRECIGOUT, E

LHOSTIS, M

MARCHAND, A

SCHREVEL, J

机构：

[1] UFR BIOL HUMAINE & EXPTL, HEMATOL LAB, F-75270 PARIS 06, FRANCE

[2] HOP HOTEL DIEU, PARASITOL LAB, F-76031 ROUEN, FRANCE

[3] CNRS, URA 40, BIOL CELLULAIRE LAB, F-86022 POITIERS, FRANCE

[4] ECOLE NATL VET NANTES, PARASITOL LAB, F-44087 NANTES 03, FRANCE

来源：

PARASITOLOGY RESEARCH | 1991年 / 77卷 / 01期

关键词：

D O I：

10.1007/BF00934377

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A continuous in vitro culture system for Babesia divergens was initiated from a human isolate. It was maintained through 305 subcultures for 3 years using a low concentration of serum and a low haematocrit, with no decrease in the initial virulence. This in vitro system enabled the routine culture of all human and bovine B. divergens isolates thus far tested, with a mean parasitaemia level of 30%-40%. Different cytological aspects observed in the same isolate by optical and electron microscopy were described in parasitized ox, gerbil and human erythrocytes. The sequence of B. divergens antibody responses was determined in man and ox, enabling the precise identification of major B. divergens antigens as candidates for vaccines. © 1991 Springer-Verlag.

引用

页码：3 / 12

页数：10

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