INHIBITION OF BOVINE PAPILLOMAVIRUS PLASMID DNA-REPLICATION BY ADENOASSOCIATED VIRUS

被引：60

作者：

HERMONAT, PL ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP,DEPT MICROBIOL & IMMUNOL,LITTLE ROCK,AR 72205

来源：

VIROLOGY | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)90710-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The helper-dependent human parvovirus adeno-associated virus type 2 (AAV) inhibits both the oncogenic transforming abilities and the DNA replication of its helper viruses, adenovirus (Ad), and herpes simplex virus (HSV). As AAV-2 also inhibits the transforming ability of bovine papillomavirus type 1 (BPV), AAV-2 was assayed for its ability to inhibit BPV plasmid DNA replication. Here we find that the AAV-2 Rep78 gene is able to trans-inhibit BPV plasmid DNA replication and that the AAV-2 terminal repeats (TR) are also cis-required for the full inhibitory effect of AAV-2. When both the AAV-2 Rep78 open reading frame and TRs are present the inhibition of BPV plasmid DNA replication is very strong. © 1992.

引用

页码：329 / 333

页数：5

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