Kainic acid as conformationally constrained glutamic acid analog in peptide synthesis

被引：8

作者：

Artuso, F

Sindona, G

Athanassopoulos, C

Stavropoulos, G

Papaioannou, D ^{[2
]}

机构：

[1] UNIV CALABRIA, DEPT CHEM, I-87030 ARCAVACATA, ITALY

[2] UNIV PATRAS, DEPT CHEM, GR-26500 PATRAI, GREECE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)02000-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic protocol is described which allows the incorporation of the gamma-amide (Kan) and the gamma-benzyl ester [Kai(Bzl)] and ether [Kol(Bzl)] of kainic acid (Kai) into peptide chains as exemplified with the synthesis of the substance P (SP) analogs [Kan(5)]-SP5-11, [Glp(5), Kan(6)]-SP5-11, [Kan(6)]-SP6-11, [Glp(5), Kai(Bzl)(11)]-SP5-11 and [Glp(5), Kol(Bzl)(11)]-SP5-11.

引用

收藏

页码：9309 / 9312

页数：4

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