OPIOID DOPAMINERGIC MECHANISMS IN THE POTENTIATION OF D-AMPHETAMINE DISCRIMINATION BY INTERFERON-ALPHA

被引：31

作者：

HO, BT ^{[1
]}

HUO, YY ^{[1
]}

LU, JG ^{[1
]}

TANSEY, LW ^{[1
]}

LEVIN, VA ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT NUCL MED,HOUSTON,TX 77030

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 01期

关键词：

INTERFERON-ALPHA; D-AMPHETAMINE; NALOXONE; OPIOID; DOPAMINE; DISCRIMINATIVE RESPONDING;

D O I：

10.1016/0091-3057(92)90446-M

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In rats trained to discriminate 0.8 mg/kg IP d-amphetamine from 1 ml/kg saline, 4 x 10(6) U/kg of recombinant human interferon-alpha (rIFN-alpha) given intramuscularly 1 h prior to tests potentiated responses elicited by 0.4 mg/kg d-amphetamine. Coadministration of the opioid receptor antagonist naloxone (I mg/kg IP) with rIFN-alpha suppressed the potentiation of d-amphetamine by the cytokine. Opioid-dopaminergic mechanisms are proposed to explain the action of rIFN-alpha.

引用

页码：57 / 60

页数：4