EFFECTS OF NITRIC-OXIDE ON RED-BLOOD-CELLS - CHANGES IN ERYTHROCYTE RESISTANCE TO HYPOTONIC HEMOLYSIS AND POTASSIUM EFFLUX BY EXPERIMENTAL MANEUVERS THAT DECREASE NITRIC-OXIDE

被引：24

作者：

CARAMELO, C ^{[1
]}

RIESCO, A ^{[1
]}

OUTEIRINO, J ^{[1
]}

MILLAS, I ^{[1
]}

BLUM, G ^{[1
]}

MONZU, B ^{[1
]}

CASADO, V ^{[1
]}

SANCHEZ, L ^{[1
]}

MOSQUERA, JR ^{[1
]}

CASADO, S ^{[1
]}

FARRE, AL ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,FDN JIMENEZ DIAZ,INST INVEST MED,E-28040 MADRID,SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine the role of nitric oxide (NO)-dependent mechanisms on erythrocyte properties, we exposed red cells to L-arginine competitive analogues, 8Br-cyclic guanosine monophosphate (8Br-cGMP) and neutrophil-eliminating filters. These treatments significantly decreased hypotonic hemolysis, increased potassium efflux and caused a spiculate change in erythrocyte morphology. These effects were related to a decrease of NO caused by the three types of treatments. (C) 1994 Academic Press, Inc.

引用

页码：447 / 454

页数：8

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