ENANTIOSELECTIVE SYNTHESIS OF NAPROXEN

被引:2
作者
DUH, TH
LIN, SJ
WANG, YF
WU, MJ
机构
[1] KAOHSIUNG MED COLL,SCH PHARM,KAOHSIUNG 80708,TAIWAN
[2] KAOHSIUNG MED COLL,SCH CHEM,KAOHSIUNG 80708,TAIWAN
关键词
NAPROXEN; ANTIINFLAMMATORY; ENANTIOSELECTIVE;
D O I
10.1002/jccs.199200080
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The optically active naproxen was synthesized in good chemical yield and high optical purity starting from a chiral alpha-ketoalcohol which was prepared from enzymatic resolution of the corresponding racemic acetate using lipase as a catalyst.
引用
收藏
页码:465 / 469
页数:5
相关论文
共 12 条
[1]  
DUH TH, UNPUB
[2]  
GIORDANO C, 1982, J CHEM SOC P1, V1, P2575
[3]   ASYMMETRIC-SYNTHESIS OF 2-ARYLPROPIONIC ACIDS [J].
GONZALEZ, A .
SYNTHETIC COMMUNICATIONS, 1991, 21 (12-13) :1353-1360
[4]   NONSTEROIDAL ANTIINFLAMMATORY AGENTS .1. 6-SUBSTITUTED 2-NAPHTHYLACETIC ACIDS [J].
HARRISON, IT ;
LEWIS, B ;
NELSON, P ;
ROOKS, W ;
ROSZKOWS.A ;
TOMOLONI.A ;
FRIED, JH .
JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (02) :203-&
[5]  
HIYAMA T, 1986, SYNTHESIS-STUTTGART, P689
[6]  
KAWKI N, 1983, CHEM PHARM BULL, V31, P3139
[7]   METHODS FOR THE SYNTHESIS OF ANTIINFLAMMATORY 2-ARYL PROPIONIC ACIDS [J].
RIEU, JP ;
BOUCHERLE, A ;
COUSSE, H ;
MOUZIN, G .
TETRAHEDRON, 1986, 42 (15) :4095-4131
[8]   STEREOSPECIFIC 1,2-ARYL MIGRATION IN 2-HYDROXY ALKYL ARYL ACETALS WITH PPH3/CCL4 - SYNTHESES OF OPTICALLY-ACTIVE IBUPROFEN AND NAPROXEN [J].
SONAWANE, HR ;
NANJUNDIAH, BS ;
KULKARNI, DG ;
AHUJA, JR .
TETRAHEDRON-ASYMMETRY, 1991, 2 (04) :251-252
[9]   A NEW METHOD FOR THE SYNTHESIS OF ALPHA-ARYLALKANOIC ACIDS BY THE USE OF 1,2-REARRANGEMENT OF THE ARYL GROUP [J].
TSUCHIHASHI, G ;
KITAJIMA, K ;
MITAMURA, S .
TETRAHEDRON LETTERS, 1981, 22 (43) :4305-4308
[10]  
TSUCHIHASHI G, 1982, TETRAHEDRON LETT, V23, P5427