SPERMATOGENESIS FOLLOWING MALE GERM-CELL TRANSPLANTATION

被引：1180

作者：

BRINSTER, RL

ZIMMERMANN, JW

机构：

[1] Lab. of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia

[2] Department of Biology, University of Pennsylvania, Philadelphia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 24期

关键词：

SPERMATOGONIA; STEM CELLS; TESTES; TRANSGENIC MICE;

D O I：

10.1073/pnas.91.24.11298

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the adult male, a population of diploid stem-cell spermatogonia continuously undergoes self-renewal and produces progeny cells, which initiate the complex process of cellular differentiation that results in mature spermatozoa. We report here that stem cells isolated from testes of donor male mice will repopulate sterile testes when injected into seminiferous tubules. Donor cell spermatogenesis in recipient testes showed normal morphological characteristics and produced mature spermatozoa. This methodology, besides opening new avenues of basic research into spermatogenesis and stem-cell self-renewal, may prove useful as a tool for biomedical science and biotechnology.

引用

页码：11298 / 11302

页数：5

共 25 条

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