ANXIOLYTIC PROFILES OF ALPRAZOLAM AND ETHANOL IN THE ELEVATED PLUS-MAZE TEST AND THE EARLY ACQUISITION OF SHUTTLEBOX AVOIDANCE

被引：32

作者：

PRUNELL, M ^{[1
]}

ESCORIHUELA, RM ^{[1
]}

FERNANDEZTERUEL, A ^{[1
]}

NUNEZ, JF ^{[1
]}

TOBENA, A ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,FAC MED,DEPT FARMACOL & PSIQUIATRIA,UNITAT PSICOL MED,E-08193 BARCELONA,SPAIN

来源：

PHARMACOLOGICAL RESEARCH | 1994年 / 29卷 / 01期

关键词：

PLUS-MAZE; SHUTTLEBOX ACQUISITION; CORRELATIONS; ANXIETY MODELS; ETHANOL; ALPRAZOLAM;

D O I：

10.1016/1043-6618(94)80096-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats pretreated either with the anxiolytic triazolobenzodiazepine alprazolam (0.75 and 1.75 mg kg-1 i.p.) or ethanol (1, 2, 3 and 4 g kg-1 p.o.) were tested in both the elevated plus-maze and the early acquisition of shuttlebox avoidance. Both substances induced overall anxiolytic effects in the plus-maze, with the 0.75 mg kg-1 being the most effective alprazolam dose and 1-3 g kg-1 being the most effective ethanol doses. Both drugs were also anxiolytic in the shuttlebox, since 1.75 mg kg-1 alprazolam and 2-3 g kg-1 ethanol improved acquisition of the task. Correlational and factor analysis showed that behaviour in the open arms of the plus-maze and efficiency in shuttlebox avoidance acquisition are positively associated, thus providing further support to the contention that the early acquisition of shuttlebox avoidance is an animal model of anxiety. © 1994 The Italian Pharmacological Society.

引用

页码：37 / 46

页数：10

共 39 条

[1] RAPID CHANGES IN GABA BINDING INDUCED BY STRESS IN DIFFERENT AREAS OF THE RAT-BRAIN [J].