QUINAZOLINE ANTIFOLATES INHIBITING THYMIDYLATE SYNTHASE - SYNTHESIS OF 4 OLIGO(L-GAMMA-GLUTAMYL) CONJUGATES OF N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID AND THEIR ENZYME-INHIBITION

被引:36
作者
PAWELCZAK, K [1 ]
JONES, TR [1 ]
KEMPNY, M [1 ]
JACKMAN, AL [1 ]
NEWELL, DR [1 ]
KRZYZANOWSKI, L [1 ]
RZESZOTARSKA, B [1 ]
机构
[1] INST CANC RES, DRUG DEV SECT, SUTTON SM2 5NG, SURREY, ENGLAND
关键词
D O I
10.1021/jm00121a029
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:160 / 165
页数:6
相关论文
共 57 条
  • [1] ALLEGRA CJ, 1985, J BIOL CHEM, V260, P9720
  • [2] SYNTHESIS OF MONOAMIDES OF METHOTREXATE FROM L-GLUTAMIC ACID MONOAMIDE TERT-BUTYL ESTERS
    ANTONJUK, DJ
    BOADLE, DK
    CHEUNG, HTA
    TRAN, TQ
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (09): : 1989 - 2003
  • [3] STUDIES ON SPECIFIC CHEMICAL FISSION OF PEPTIDE LINKS .1. THE REARRANGEMENT OF ASPARTYL AND GLUTAMYL PEPTIDES
    BATTERSBY, AR
    ROBINSON, JC
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1955, : 259 - 269
  • [4] INNERMOLEKULARE, PARTIELLE ALPHA-]GAMMA-TRANSPEPTIDIERUNG DER ALPHA-POLYGLUTAMINSAURE
    BRUCKNER, V
    KOVACS, J
    MEDZIHRADSZKY, K
    [J]. NATURWISSENSCHAFTEN, 1955, 42 (04) : 96 - 97
  • [5] A PHASE-I EVALUATION OF THE QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITOR, N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, CB3717
    CALVERT, AH
    ALISON, DL
    HARLAND, SJ
    ROBINSON, BA
    JACKMAN, AL
    JONES, TR
    NEWELL, DR
    SIDDIK, ZH
    WILTSHAW, E
    MCELWAIN, TJ
    SMITH, IE
    HARRAP, KR
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) : 1245 - 1252
  • [6] POLYGLUTAMATION OF METHOTREXATE - IS METHOTREXATE A PRODRUG
    CHABNER, BA
    ALLEGRA, CJ
    CURT, GA
    CLENDENINN, NJ
    BARAM, J
    KOIZUMI, S
    DRAKE, JC
    JOLIVET, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (03) : 907 - 912
  • [7] CHENG YC, 1985, CANCER RES, V45, P598
  • [8] CLAYTON DW, 1953, CHEM IND-LONDON, P1205
  • [9] CLAYTON DW, 1956, J CHEM SOC, P371
  • [10] 7,8-DIHYDROPTEROYL OLIGO-GAMMA-L-GLUTAMATES - SYNTHESIS AND KINETIC STUDIES WITH PURIFIED DIHYDROFOLATE-REDUCTASE FROM MAMMALIAN SOURCES
    COWARD, JK
    PARAMESWARAN, KN
    CASHMORE, AR
    BERTINO, JR
    [J]. BIOCHEMISTRY, 1974, 13 (19) : 3899 - 3903