QUINAZOLINE ANTIFOLATES INHIBITING THYMIDYLATE SYNTHASE - SYNTHESIS OF 4 OLIGO(L-GAMMA-GLUTAMYL) CONJUGATES OF N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID AND THEIR ENZYME-INHIBITION

被引:36
作者
PAWELCZAK, K [1 ]
JONES, TR [1 ]
KEMPNY, M [1 ]
JACKMAN, AL [1 ]
NEWELL, DR [1 ]
KRZYZANOWSKI, L [1 ]
RZESZOTARSKA, B [1 ]
机构
[1] INST CANC RES, DRUG DEV SECT, SUTTON SM2 5NG, SURREY, ENGLAND
关键词
D O I
10.1021/jm00121a029
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:160 / 165
页数:6
相关论文
共 57 条
  • [51] FORMATION AND RETENTION AND BIOLOGICAL-ACTIVITY OF N10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (CB3717) POLYGLUTAMATES IN L1210 CELLS-INVITRO
    SIKORA, E
    JACKMAN, AL
    NEWELL, DR
    CALVERT, AH
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (21) : 4047 - 4054
  • [52] SIKORA E, 1986, BRIT J CANCER, V54, P178
  • [53] IMIDES FROM ASPARAGINE AND GLUTAMINE .2. ALPHA-AMINOGLUTARIMIDE
    SONDHEIMER, E
    HOLLEY, RW
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (14) : 3767 - 3770
  • [54] Zone behavior of enzymes - Illustrated by the effect of dissociation constant and dilution on the system cholinesterase-physostigmine
    Straus, OH
    Goldstein, A
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 1943, 26 (06) : 559 - 585
  • [55] HUMAN THYMIDYLATE SYNTHETASE .3. EFFECTS OF METHOTREXATE AND FOLATE ANALOGS
    SZETO, DW
    CHENG, YC
    ROSOWSKY, A
    YU, CS
    MODEST, EJ
    PIPER, JR
    TEMPLE, C
    ELLIOTT, RD
    ROSE, JD
    MONTGOMERY, JA
    [J]. BIOCHEMICAL PHARMACOLOGY, 1979, 28 (17) : 2633 - 2637
  • [56] UEDA T, 1986, MOL PHARMACOL, V30, P149
  • [57] [No title captured]