NOVEL SYNTHESIS OF APORPHINES VIA 3-PHENYLPHENETHYLAMINES

被引：9

作者：

GERECKE, M

BROSSI, A

机构：

[1] Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd., Basel

[2] Section of Medicinal Chemistry, Niamdd, National Institutes of Health, Bethesda, Maryland

来源：

HELVETICA CHIMICA ACTA | 1979年 / 62卷 / 05期

关键词：

D O I：

10.1002/hlca.19790620520

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

rac‐1,2,10‐Trimethoxy‐aporphine (14) and rac‐2‐ethoxy‐10,11‐dimethoxyaporphine (27) have been synthesized from the 3‐phenylphenethylamines 9 and 22 by a new route. The 8‐phenyl‐3,4‐dihydroisoquinolines 11 and 24, the oxo‐aporphines 12 and 25 and the rac‐nor‐aporphines 13 and 26 were obtained as intermediates. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1549 / 1558

页数：10