NOVEL SYNTHESIS OF APORPHINES VIA 3-PHENYLPHENETHYLAMINES

被引:9
作者
GERECKE, M
BROSSI, A
机构
[1] Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd., Basel
[2] Section of Medicinal Chemistry, Niamdd, National Institutes of Health, Bethesda, Maryland
关键词
D O I
10.1002/hlca.19790620520
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
rac‐1,2,10‐Trimethoxy‐aporphine (14) and rac‐2‐ethoxy‐10,11‐dimethoxyaporphine (27) have been synthesized from the 3‐phenylphenethylamines 9 and 22 by a new route. The 8‐phenyl‐3,4‐dihydroisoquinolines 11 and 24, the oxo‐aporphines 12 and 25 and the rac‐nor‐aporphines 13 and 26 were obtained as intermediates. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim
引用
收藏
页码:1549 / 1558
页数:10
相关论文
共 22 条
  • [11] PSCHORR A, 1912, LIEBIGS ANN CHEM, V391, P32
  • [12] Raiford L. C., 1932, J AM CHEM SOC, V54, P1092
  • [13] SHAMMA M, 1973, ISOQUINOLINE ALKALOI, P194
  • [14] SHAMMA M, 1975, ALKALOIDS, V5, P134
  • [15] SHAMMA M, 1978, ISOQUINOLINE ALKALOI, P123
  • [16] SHAMMA M, 1977, APORPHINOIDS, V7, P152
  • [17] SHAMMA M, 1978, ALKALOIDS, V8, P122
  • [18] SHAMMA M, 1974, ALKALOIDS LONDON, V4, P197
  • [19] SHAMMA M, 1976, ALKALOIDS, V6, P170
  • [20] SHAMMA M, 1973, ALKALOIDS, V3, P116