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DOES AMINOTRIAZOLE INHIBIT IMPORT OF CATALASE INTO PEROXISOMES BY RETARDING UNFOLDING

被引：28
作者：
MIDDELKOOP, E
STRIJLAND, A
TAGER, JM
机构：
[1] E.C. Slater Institute for Biochemical Research, University of Amsterdam, Academic Medical Centre, 1105 AZ Amsterdam
来源：
FEBS LETTERS | 1991年 / 279卷 / 01期
关键词：
PEROXISOME; ZELLWEGER SYNDROME; CATALASE; IMPORT OF PROTEINS; UNFOLDING;
D O I：
10.1016/0014-5793(91)80255-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fusion of complementary cell lines from patients with diseases of peroxisome biogenesis leads to peroxisome assembly in the heterokaryons and to uptake of cytosolic catalase by the newly assembled peroxisomes. Here we show that catalase import is inhibited by prior binding to catalase of the inhibitor 3-amino-1,2,4-triazole, which appears to retard unfolding of the protein.
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页码：79 / 82
页数：4
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