CHARACTERIZATION OF 3 OVERLAPPING DELETIONS CAUSING X-LINKED LYMPHOPROLIFERATIVE DISEASE

被引：30

作者：

SKARE, J

WU, BL

MADAN, S

PULIJAAL, V

PURTILO, D

HABER, D

NELSON, D

SYLLA, B

GRIERSON, H

NITOWSKY, H

GLASER, J

WISSINK, J

WHITE, B

HOLDEN, J

HOUSMAN, D

LENOIR, G

WYANDT, H

MILUNSKY, A

机构：

[1] BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA

[2] BOSTON UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02118 USA

[3] BOSTON UNIV, SCH MED, DEPT MICROBIOL, BOSTON, MA 02118 USA

[4] BOSTON UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02118 USA

[5] BOSTON UNIV, SCH MED, CTR HUMAN GENET, BOSTON, MA 02118 USA

[6] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT OBSTET & GYNECOL, BRONX, NY 10461 USA

[7] UNIV NEBRASKA, MED CTR, DEPT PATHOL & MICROBIOL, OMAHA, NE 68105 USA

[8] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[9] INT AGCY RES CANC, F-69372 LYON, FRANCE

[10] MCMASTER UNIV, DEPT BIOL, HAMILTON L8S 4L8, ONTARIO, CANADA

[11] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT PEDIAT, BRONX, NY 10461 USA

[12] QUEENS UNIV, DEPT PSYCHIAT, KINGSTON K7L 3N6, ONTARIO, CANADA

[13] BRONX JACOBI HOSP, DEPT INFECT DIS, BRONX, NY USA

来源：

GENOMICS | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1169

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Blot hybridization was used to find DNA sequences missing in a male who lacked two-thirds of Xq25. The probes were used to (discover two additional males with deletions resulting in X-linked lymphoproliferative disease (XLP). All three deletions have a region in common, and DXS739 is within this candidate region. The new deletions were also detectable rising chromosome banding, and the smallest removes only one-third of Xq25. XLP is the only consequence of the deletions. © 1993 Academic Press, Inc.

引用

页码：254 / 255

页数：2

共 11 条

[1] EPSTEIN-BARR VIRUS-INFECTIONS IN MALES WITH THE X-LINKED LYMPHOPROLIFERATIVE SYNDROME [J].