DELAYED-HYPERSENSITIVITY, IMMUNE DEVIATION, ANTIGEN-PROCESSING AND T-CELL SUBSET-SELECTION IN SYPHILIS PATHOGENESIS AND VACCINE DESIGN

被引:28
作者
SELL, S [1 ]
HSU, PL [1 ]
机构
[1] UNIV ARKANSAS, DEPT PATHOL, LITTLE ROCK, AR 72205 USA
来源
IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期
关键词
D O I
10.1016/0167-5699(93)90196-R
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T-cell mediated delayed-type hypersensitivity (DTH) is the predominant immune mechanism for clearing tissues of infecting organisms in the primary lesion of syphilis. Here, Stewart Sell and Pei-Ling Hsu propose a strategy for vaccination against syphilis in which selective induction of DTH may be accomplished by using BCG vectored vaccines containing selected DNA sequences for T. pallidum antigens.
引用
收藏
页码:576 / 582
页数:7
相关论文
共 65 条
[1]  
BAKERZANDER S, 1980, AM J PATHOL, V101, P387
[2]  
BLANCO DR, 1990, J IMMUNOL, V144, P1914
[3]  
BLOOM BR, 1989, REV INFECT DIS, V11, pS460
[4]   SELECTIVE SUPPRESSION OF DELAYED HYPERSENSITIVITY BY INDUCTION OF IMMUNOLOGIC TOLERANCE [J].
BOREL, Y ;
FAUCONNET, M ;
MIESCHER, PA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 123 (04) :585-+
[5]  
BORENSTEIN LA, 1988, J IMMUNOL, V140, P2415
[6]  
BOYDEN SV, 1957, BRIT J EXP PATHOL, V38, P611
[7]  
Calmette A, 1927, VACCINATION PREVENTI
[8]   GENETIC AND PHYSICOCHEMICAL CHARACTERIZATION OF THE RECOMBINANT DNA-DERIVED 47-KILODALTON SURFACE IMMUNOGEN OF TREPONEMA-PALLIDUM SUBSP PALLIDUM [J].
CHAMBERLAIN, NR ;
RADOLF, JD ;
HSU, PL ;
SELL, S ;
NORGARD, MV .
INFECTION AND IMMUNITY, 1988, 56 (01) :71-78
[9]   ACYLATION OF THE 47-KILODALTON MAJOR MEMBRANE IMMUNOGEN OF TREPONEMA-PALLIDUM DETERMINES ITS HYDROPHOBICITY [J].
CHAMBERLAIN, NR ;
DEOGNY, L ;
SLAUGHTER, C ;
RADOLF, JD ;
NORGARD, MV .
INFECTION AND IMMUNITY, 1989, 57 (09) :2878-2885
[10]   MAJOR INTEGRAL MEMBRANE-PROTEIN IMMUNOGENS OF TREPONEMA-PALLIDUM ARE PROTEOLIPIDS [J].
CHAMBERLAIN, NR ;
BRANDT, ME ;
ERWIN, AL ;
RADOLF, JD ;
NORGARD, MV .
INFECTION AND IMMUNITY, 1989, 57 (09) :2872-2877