SYNTHESIS OF A 5'-THIOPHOSPHATE ANALOG OF 2-5A, A PHOSPHATASE RESISTANT ACTIVATOR OF THE 2-5A-DEPENDENT RIBONUCLEASE

被引：27

作者：

XIAO, W

LI, GY

LESIAK, K

DONG, BH

SILVERMAN, RH

TORRENCE, PF

机构：

[1] NIDDK,MED CHEM LAB,BIOMED CHEM SECT,BETHESDA,MD 20892

[2] US FDA,CTR BIOL EVALUAT & RES,DIV ALLERGEN PROD & PARASITOL,BIOPHYS LAB,BETHESDA,MD 20892

[3] CLEVELAND CLIN FDN,RES INST,DEPT CANC BIOL,CLEVELAND,OH 44195

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80294-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 5'-thiophosphate analogue of the small oligonucleotide mediator of the anti-picornavirus action of interferon was synthesized and shown to be highly resistant to enzymic 5'-dephosphorylation and to activate the 2-5A-dependent ribonuclease as effectively as parent p5'A2'p5'A2'p5'A itself.

引用

页码：2609 / 2614

页数：6

共 14 条

[1] DONG BH, 1994, J BIOL CHEM, V269, P14153
[2] INVESTIGATION OF ENZYME MECHANISMS WITH NUCLEOSIDE PHOSPHOROTHIOATES
ECKSTEIN, F
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1975, 14 (03) : 160 - 166
[3] PHOSPHOROTHIOATE ANALOGS OF NUCLEOTIDES - TOOLS FOR THE INVESTIGATION OF BIOCHEMICAL PROCESSES
ECKSTEIN, F
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1983, 22 (06) : 423 - 439
[4] PHOSPHOROTHIOATE ANALOGS OF NUCLEOTIDES
ECKSTEIN, F
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1979, 12 (06) : 204 - 210
[5] A CHEMICAL 5'-PHOSPHORYLATION OF OLIGODEOXYRIBONUCLEOTIDES THAT CAN BE MONITORED BY TRITYL CATION RELEASE
HORN, T
URDEA, MS
[J]. TETRAHEDRON LETTERS, 1986, 27 (39) : 4705 - 4708
[6] 3H-1,2-BENZODITHIOLE-3-ONE 1,1-DIOXIDE AS AN IMPROVED SULFURIZING REAGENT IN THE SOLID-PHASE SYNTHESIS OF OLIGODEOXYRIBONUCLEOSIDE PHOSPHOROTHIOATES
IYER, RP
EGAN, W
REGAN, JB
BEAUCAGE, SL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (03) : 1253 - 1254
[7] JOHNSTON ML, 1984, INTERFERON MECHANISM, P189
[8] 2',5'-OLIGOADENYLATE - ANTISENSE CHIMERAS SYNTHESIS AND PROPERTIES
LESIAK, K
KHAMNEI, S
TORRENCE, PF
[J]. BIOCONJUGATE CHEMISTRY, 1993, 4 (06) : 467 - 472
[9] FUNCTIONAL-ANALYSIS OF 2-5A-DEPENDENT RNASE AND 2-5A USING 2',5'-OLIGOADENYLATE-CELLULOSE
SILVERMAN, RH
[J]. ANALYTICAL BIOCHEMISTRY, 1985, 144 (02) : 450 - 460
[10] CHEMICAL SYNTHESIS AND BIOLOGICAL CHARACTERIZATION OF PHOSPHOROTHIOATE ANALOGS OF 2',5'-3'-DEOXYADENYLATE TRIMER
SOBOL, RW
CHARUBALA, R
PFLEIDERER, W
SUHADOLNIK, RJ
[J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (10) : 2437 - 2443

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