SYNTHESIS OF A 5'-THIOPHOSPHATE ANALOG OF 2-5A, A PHOSPHATASE RESISTANT ACTIVATOR OF THE 2-5A-DEPENDENT RIBONUCLEASE

被引：27

作者：

XIAO, W

LI, GY

LESIAK, K

DONG, BH

SILVERMAN, RH

TORRENCE, PF

机构：

[1] NIDDK,MED CHEM LAB,BIOMED CHEM SECT,BETHESDA,MD 20892

[2] US FDA,CTR BIOL EVALUAT & RES,DIV ALLERGEN PROD & PARASITOL,BIOPHYS LAB,BETHESDA,MD 20892

[3] CLEVELAND CLIN FDN,RES INST,DEPT CANC BIOL,CLEVELAND,OH 44195

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80294-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 5'-thiophosphate analogue of the small oligonucleotide mediator of the anti-picornavirus action of interferon was synthesized and shown to be highly resistant to enzymic 5'-dephosphorylation and to activate the 2-5A-dependent ribonuclease as effectively as parent p5'A2'p5'A2'p5'A itself.

引用

页码：2609 / 2614

页数：6

共 14 条

[11] OLIGONUCLEOTIDE STRUCTURAL PARAMETERS THAT INFLUENCE BINDING OF 5'-O-TRIPHOSPHOADENYLYL-(2'-]5')-ADENYLYL-(2'-]5')-ADENOSINE TO THE 5'-O-TRIPHOSPHOADENYLYL-(2'-]5')-ADENYLYL-(2'-]5')-ADENOSINE DEPENDENT ENDORIBONUCLEASE - CHAIN-LENGTH, PHOSPHORYLATION STATE, AND HETEROCYCLIC BASE
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) : 1300 - 1304
[13] Voet D., 1990, BIOCHEMISTRY-US, p[741, 749]
[14] EXPRESSION CLONING OF 2-5A-DEPENDENT RNASE - A UNIQUELY REGULATED MEDIATOR OF INTERFERON ACTION
ZHOU, AM
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[J]. CELL, 1993, 72 (05) : 753 - 765

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