DOUBLE-BLIND TRIAL OF BESTATIN IN HIV-POSITIVE PATIENTS

被引：5

作者：

HORDING, M

GOTZSCHE, PC

CHRISTENSEN, LD

BYGBJERG, IC

FABER, V

机构：

[1] Department of Infectious Diseases, The AIDS Laboratory M 7705, Rigshospitalet, DK-2200 Copenhagen N

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1990年 / 44卷 / 09期

关键词：

D O I：

10.1016/0753-3322(90)90208-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface, marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected. bestatin / immunomodulation / HIV therapy. © 1990.

引用

页码：475 / 478

页数：4