SYNERGISTIC EFFECT OF FLAVONES AND FLAVONOLS AGAINST HERPES-SIMPLEX VIRUS TYPE-1 IN CELL-CULTURE - COMPARISON WITH THE ANTIVIRAL ACTIVITY OF PROPOLIS

被引：244

作者：

AMOROS, M ^{[1
]}

SIMOES, CMO ^{[1
]}

GIRRE, L ^{[1
]}

SAUVAGER, F ^{[1
]}

CORMIER, M ^{[1
]}

机构：

[1] UNIV RENNES 1,FAC PHARM,MICROBIOL PHARMACEUT LAB,F-35010 RENNES,FRANCE

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 12期

关键词：

D O I：

10.1021/np50090a003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.

引用

页码：1732 / 1740

页数：9

共 31 条

[21]

NAGY E, 1985, FLAVONOIDS BIOFLAVON, P223

[22]

PAYMENT P, 1989, MANUEL TECHNIQUES VI, P16

[23] MECHANISM OF QUERCETIN OXYGENATION A POSSIBLE MODEL FOR HEME DEGRADATION [J].

RAJANANDA, V ;

BROWN, SB .

TETRAHEDRON LETTERS, 1981, 22 (43) :4331-4334

[24] EFFECT OF COMBINATIONS OF ACYCLOVIR WITH VIDARABINE OR ITS 5'-MONOPHOSPHATE ON HERPES-SIMPLEX VIRUSES IN CELL-CULTURE AND IN MICE [J].

SCHINAZI, RF ;

PETERS, J ;

WILLIAMS, CC ;

CHANCE, D ;

NAHMIAS, AJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 22 (03) :499-507

[25]

Selway J W, 1986, Prog Clin Biol Res, V213, P521

[26]

TSUCHIYA Y, 1985, CHEM PHARM BULL, V9, P3881

[27]

VANDENBERGHE DA, 1986, B I PASTEUR, V84, P101

[28]

VANHAELEN M, 1979, J PHARM BELG, V34, P253

[29]

VLIETINCK AJ, 1986, PLANT FLAVONOIDS BIO, V213, P283

[30] ANTIVIRAL ACTIVITY OF FLAVONES AND POTENTIATION BY ASCORBATE [J].

VRIJSEN, R ;

EVERAERT, L ;

BOEYE, A .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :1749-1751

← 1 2 3 4 →