HYBRIDIZATION PROPERTIES OF A DEOXYOLIGONUCLEOTIDE CONTAINING 4 FORMACETAL LINKAGES

被引：18

作者：

MATTEUCCI, M

机构：

[1] Gilead Sciences, Inc., Foster City, CA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046449

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deoxyoligonucleotide TCTCTCTCTCTTTT bearing four formacetal linkages has been synthesized. The hybridization properties of this compound with complementary RNA and single stranded DNA has been compared to control sequences bearing phosphodiester, phosphoramidate and methylphosphonate linkages. The formacetal oligomer hybridizes to RNA similarly to a diester and significantly better than the other neutral linkages.

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页码：231 / 234

页数：4

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