PRIMING AS A MODEL OF BEHAVIORAL SENSITIZATION

被引：18

作者：

DICHIARA, G

MORELLI, M

BARONE, P

PONTIERI, F

机构：

[1] UNIV CAGLIARI,DEPT TOXICOL,I-09100 CAGLIARI,ITALY

[2] UNIV NAPLES,DEPT CLIN NEUROL,I-80138 NAPLES,ITALY

[3] UNIV ROMA LA SAPIENZA,DEPT NEUROL SCI,I-00185 ROME,ITALY

来源：

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1992年 / 18卷 / 3-4期

关键词：

BASAL GANGLIA; BEHAVIOR; DOPAMINE; PRIMING; SENSITIZATION;

D O I：

10.1159/000480624

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Repeated exposure to drugs acting as direct or indirect stimulants of central dopamine transmission results in sensitization to their behavioural stimulant properties (behavioural sensitization). Priming provides a simple model of behavioural sensitization particularly suitable for studies of its neural and molecular mechanisms. The results obtained to date indicate that priming results in an increased responsiveness of postsynaptic dopamine receptor mechanisms in the caudate nucleus, possibly due to an increased affinity of the D-1 receptor for its agonist.

引用

页码：223 / 227

页数：5

共 12 条

[1]

CRISWELL H, 1989, J NEUROSCI, V9, P125

[2] DOPAMINE TRANSMISSION IN THE INITIATION AND EXPRESSION OF DRUG-INDUCED AND STRESS-INDUCED SENSITIZATION OF MOTOR-ACTIVITY [J].