SYNTHESIS OF D-BIOTIN CHIRAL INTERMEDIATES VIA A BIOCHEMICAL METHOD

被引：10

作者：

YAMANO, T

TOKUYAMA, S

AOKI, I

NISHIGUCHI, Y

NAKAHAMA, K

TAKANOHASHI, K

机构：

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1993年 / 66卷 / 05期

关键词：

D O I：

10.1246/bcsj.66.1456

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enzyme-catalyzed kinetic resolution of (+/-)-(3aalpha,4alpha,6aalpha)-4-acetoxy-1,3-dibenzyl-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one [(RS)-(3a)] was examined. Lipase B from Pseudomonas fragi and rabbit liver esterase gave (-)-[3aR-(3aalpha,4alpha,6aalpha)]-1,3-dibenzyl-3a,4,6,6a-tetrahydro-4-hydroxy-1H-thieno[3,4-Aimidazol-2(3H)-one [(R)-(2)], while Streptomyces rochei var. volubilis gave the alcohol (S)-(2), which is a key intermediate in the synthesis of d-biotin, with high enantioselectivity.

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页码：1456 / 1460

页数：5

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