THE EFFECT OF INHIBITION OF LEUKOTRIENE SYNTHESIS ON THE ACTIVITY OF INTERLEUKIN-8 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

被引：4

作者：

ROBERTS, PJ

PIZZEY, AR

LINCH, DC

机构：

[1] Department of Haematology, University College London Medical School, London WC1 E 6HX

[2] Department of Haematology, University College London Medical School, London WC1 E 6HX

来源：

MEDIATORS OF INFLAMMATION | 1993年 / 2卷 / 03期

关键词：

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; BETA-2-INTEGRIN; INTERLEUKIN-8; LEUKOTRIENES; 5-LIPOXYGENASE INHIBITORS; NEUTROPHIL; SUPEROXIDE;

D O I：

10.1155/S0962935193000286

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

THE cytokines interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced the extracellular release of arachidonate metabolites from ionophore-stimulated neutrophils by 145 +/- 10% (mean +/- S.E.M., n = 13) and 182 +/- 11% (n = 16), respectively. To determine whether enhanced leukotriene production mediates the effects of these cytokines on neutrophil activity, two different specific arachidonate 5-lipoxygenase (5-LO) inhibitors, piriprost and MK-886, were used to inhibit leukotriene synthesis. Neither inhibitor affected the upregulation of CD11b beta2-integrin expression or priming of superoxide generation stimulated by IL-8 and GM-CSF. It is concluded that leukotrienes do not mediate either the direct or priming effects of these cytokines and that these classes of anti-inflammatory drugs are therefore unlikely to inhibit the effects of IL-8 and GM-CSF on neutrophil activation.

引用

收藏

页码：211 / 216

页数：6

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