OXYTOCIN GENE-EXPRESSION IN RAT UTERUS

被引：169

作者：

LEFEBVRE, DL

GIAID, A

BENNETT, H

LARIVIERE, R

ZINGG, HH

机构：

[1] MCGILL UNIV,ROYAL VICTORIA HOSP,MOLEC ENDOCRINOL LAB,MONTREAL H3A 1A1,QUEBEC,CANADA

[2] MCGILL UNIV,MONTREAL GEN HOSP,MONTREAL H3A 1A1,QUEBEC,CANADA

[3] MCGILL UNIV,ROYAL VICTORIA HOSP,ENDOCRINE LAB,MONTREAL H3A 1A1,QUEBEC,CANADA

来源：

SCIENCE | 1992年 / 256卷 / 5063期

关键词：

D O I：

10.1126/science.1598587

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neurohypophyseal hormone oxytocin (OT) is the most potent uterotonic agent known and is used to induce labor. Yet, endogenous circulating OT appears not to participate in the induction of labor. As shown here, the finding of OT messenger RNA and peptide in the uterus suggests a solution for this paradox. During gestation, rat uterus OT messenger RNA increased more than 150-fold and, at term, exceeded hypothalamic OT messenger RNA by 70-fold. Thus, during parturition, OT may act primarily as a local mediator and not as a circulating hormone.

引用

页码：1553 / 1555

页数：3