TETRA-P-AMINOPHENYLPORPHYRIN CONJUGATED WITH GD-DTPA - TUMOR-SPECIFIC CONTRAST AGENT FOR MR-IMAGING

被引：43

作者：

HINDRE, F ^{[1
]}

LEPLOUZENNEC, M ^{[1
]}

DECERTAINES, JD ^{[1
]}

FOULTIER, MT ^{[1
]}

PATRICE, T ^{[1
]}

SIMONNEAUX, G ^{[1
]}

机构：

[1] UNIV RENNES 1,FAC SCI,CHIM ORGANOMETAL LAB,F-35042 RENNES,FRANCE

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 01期

关键词：

CONTRAST ENHANCEMENT; CONTRAST MEDIA; GADOLINIUM; NEOPLASMS; MR; PORPHYRIN; RELAXOMETRY;

D O I：

10.1002/jmri.1880030111

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tetra-p-aminophenylporphyrin (TPP) was conjugated with gadolinium diethylenetriaminepentaacetic acid (DTPA) and used as a contrast agent in magnetic resonance (MR) imaging to achieve tumor selectivity in nude mice. A substantial decrease in T1 was measured in excised tissues (kidneys, tumor, and liver) from mice that received the porphyrin derivative Gd2(DTPA)4 TPP. Toxicity and phototoxicity were less than those obtained with hematoporphyrin derivative in both L1210 lymphoblastic leukemia cells and HT 29 human colonic cancer cells, as determined with in vitro assays. MR images showed an enhancement of contrast between the tumor and adjacent tissue after injection of this agent. The results indicate that Gd2(DTPA)4TPP could be a useful prototype paramagnetic porphyrin MR imaging contrast agent with an affinity for tumors.

引用

页码：59 / 65

页数：7