BORON MEDIATED ONE-POT ALDOL-REDUCTION SEQUENCE - ENANTIO AND DIASTEREOSELECTIVE SYNTHESIS OF TYPICAL POLYKETIDE FRAGMENTS

被引：18

作者：

BONINI, C ^{[1
]}

RACIOPPI, R ^{[1
]}

RIGHI, G ^{[1
]}

ROSSI, L ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM,CTR STUDIO CHIM SOSTANZE ORGAN NAT,CNR,I-00185 ROME,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)86165-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

an aldol-reduction one-pot sequence allows syn-syn polyketide fragments such as 7 to be obtained enantio and diastereoselectively. Enol diisopinocampheylborinate is able to influence both the aldol and the subsequent reduction with NaBH4, via a chelate chair like intermediate.

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页码：173 / 176

页数：4

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