P-32 POSTLABELED DNA-ADDUCTS IN LIVER OBTAINED FROM WOMEN TREATED WITH TAMOXIFEN

被引:94
作者
MARTIN, EA
RICH, KJ
WHITE, INH
WOODS, KL
POWLES, TJ
SMITH, LL
机构
[1] LEICESTER ROYAL INFIRM,SCH MED,DEPT THERAPEUT & PHARMACOL,LEICESTER LE1 5WW,LEICS,ENGLAND
[2] ROYAL MARSDEN HOSP,SUTTON SM2 5PT,SURREY,ENGLAND
关键词
D O I
10.1093/carcin/16.7.1651
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P-32-Postlabelling of DNA extracted from the livers obtained from seven women receiving tamoxifen (20 mg either once or twice daily) was compared with liver DNA from seven individuals not receiving this drug. In all but one of the treated women, tamoxifen and its N-desmethyltamoxifen metabolite could be detected in liver extracts by high performance liquid chromatography; none was detected in control samples. The total level of P-32-postlabelled DNA adducts extracted from the tamoxifen treated women ranged between 18-80 adducts/10(8) nucleotides. The pattern of P-32-postlabelled adducts was not the same as those seen in rats dosed with this drug. There was no significant difference in the level of DNA damage between the tamoxifen treated and control groups. Although only a small number of subjects has so far been examined it appears that women are less susceptible to liver DNA damage caused by tamoxifen than rats.
引用
收藏
页码:1651 / 1654
页数:4
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