RELATIONSHIP BETWEEN SERUM IGE LEVELS AND ANAPHYLACTIC HISTAMINE-RELEASE FROM ISOLATED RAT MAST-CELLS

被引：15

作者：

SYDBOM, A ^{[1
]}

KARLSSON, T ^{[1
]}

机构：

[1] BIOMED CTR,DEPT MED & PHYSIOL CHEM,S-75123 UPPSALA,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 107卷 / 04期

关键词：

immunization; inbred Hooded Lister rats; pertussis vaccine; rat IgE‐radioimmunoassay;

D O I：

10.1111/j.1748-1716.1979.tb06481.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Inbred Hooded Lister rats were immunized with egg albumin with B. pertussis vaccine used as an adjuvant. The serum levels of total IgE and IgE antibody (egg albumin specific) were determined by radioimmunoassay techniques before and after immunization. The basic level of total IgE in serum was 560 ± 110 ng/ml. After immunization a maximal peak at day 11 of 1940 ± 160 ng/ml was registered. Anti‐egg albumin IgE antibody showed a maximum around day 13 of 75 ± 11 units/ml. Pleural mast cells were isolated on Ficoll between day 14 and 20 after immunization. A significant negative correlation between the basic total IgE level and histamine release by antigen (egg albumin) was found and also a significant positive correlation of specific IgE antibody (determined at day 11) and histamine release. The correlation between IgE level and histamine release was slightly improved if instead the ratio of specific IgE antibody over total IgE was used. © 1979 Scandinavian Physiological Society

引用

页码：313 / 318

页数：6

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