CONTROL OF OXIDATIVE DAMAGE IN RHEUMATOID-ARTHRITIS BY GOLD(I)-THIOLATE DRUGS

被引:21
作者
GROOTVELD, M
BLAKE, DR
SAHINOGLU, T
CLAXSON, AWD
MAPP, P
STEVENS, C
ALLEN, RE
FURST, A
机构
[1] The Inflammation Group, Bone and Joint Research Unit, The London Hospital Medical College
来源
FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 10卷 / 4-5期
关键词
Free radicals; Gold; Rheumatoid arthritis;
D O I
10.3109/10715769009149889
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The roles of anti-arthritic gold(I)-thiolate drugs such as disodium aurothiomalate ('Myocrisin' in the modulation or promotion of oxygen radical-mediated oxidative damage in vivo ate reviewed. In particular, the precise molecular mechanisms by which these novel second-line agents exert their therapeutic effects are discussed in terms of (i) the direct and indirect control of enzymes involved in the generation or scavenging of reactive oxygen speices (ROS) such as superoxide ion, hydrogen peroxide and hydroxyl radical, (ii) the protection of proteins and relevant enzyme systems against attack by ROS and (iii) their direct involvement in the production (at appropriate 'target' sites) or scavenging of ROS in vivo. In addition, the role of the orally-effective gold(I)-phosphine complex auranofin in the control of oxidative damage in rheumatoid arthritis is also discussed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:199 / 220
页数:22
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