RELATIONSHIP BETWEEN PROSTAGLANDINS AND CYCLIC-AMP IN THE PROCESS OF IMPLANTATION IN RATS

被引：9

作者：

GARG, SK ^{[1
]}

DESOUZA, AN ^{[1
]}

CHAUDHURY, RR ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES, DEPT PHARMACOL, CHANDIGARH 160012, INDIA

来源：

PROSTAGLANDINS AND MEDICINE | 1979年 / 3卷 / 01期

关键词：

D O I：

10.1016/0161-4630(79)90010-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of alloxan, a knowninhibitor of adenylate cyclase, on the levels of prostaglandins E and F was investigated in pregnant rats. Animals were treated intraluminally with alloxan in normal saline or alloxan plus cyclic-AMP in normal saline or normal saline alone on day 4 of pregnancy. The uteri were collected on days 5 and 6 of pregnancy and the prostaglandins E and F were extracted and measured by a radioimmunoassay technique. In the alloxan treated rats, a significant reduction in PGE and PGF levels was found on days 5 and 6 of pregnancy as compared to untreated control group, whereas in the alloxan plus cyclic-AMP treated group the levels of PGE and PGF were comparable to those of the untreated control group. These findings suggest a possible relationship between prostaglandins and cyclic-AMP in the process of implantation in rats. © 1979.

引用

页码：1 / 6

页数：6

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