APPLICATION OF COUNTERCURRENT CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY FOR THE IDENTIFICATION OF BIOACTIVE LIGNANS FROM PLANT NATURAL-PRODUCTS

The versatility and resolving power of countercurrent chromatography (CCC) has been demonstrated with a newly developed analytical high-speed planet centrifuge system. Interfacing countercurrent chromatography with mass spectrometry (MS) provides a new analytical methodology that integrates the advantages of countercurrent chromatography with the low detection limit and Identification capability of mass spectrometry. In this paper the capability of thermospray CCC/MS is demonstrated In Identifying and validating the bioactive and structurally known lignans from a crude extract of Schisandra rubriflora Rhed et Wils, a traditional Chinese herbal medicine for treatment of hepatitis. © 1990, American Chemical Society. All rights reserved.