STRUCTURE-ACTIVITY-RELATIONSHIPS IN DNA GYRASE INHIBITORS

被引：63

作者：

RADL, S

机构：

[1] Research Institute for Pharmacy and Biochemistry, 130 60 Prague

来源：

PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 01期

关键词：

D O I：

10.1016/0163-7258(90)90014-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The review brings the status of research into DNA gyrase inhibitors up to date. Structure-activity relationships in both coumarin antibiotics, like novobiocin or coumermycins, and quinolones are discussed. In this section dealing wigh the quinolones, promising drugs under further evaluation are pointed out. Recently discovered new types of DNA gyrase inhibitors, i.e. tetramic derivatives and biphenyl dicarboxylic acid monoamides, are also briefly mentioned. © 1990.

引用

页码：1 / 17

页数：17

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