STRUCTURE-ACTIVITY-RELATIONSHIPS IN DNA GYRASE INHIBITORS

被引:63
作者
RADL, S
机构
[1] Research Institute for Pharmacy and Biochemistry, 130 60 Prague
关键词
D O I
10.1016/0163-7258(90)90014-S
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The review brings the status of research into DNA gyrase inhibitors up to date. Structure-activity relationships in both coumarin antibiotics, like novobiocin or coumermycins, and quinolones are discussed. In this section dealing wigh the quinolones, promising drugs under further evaluation are pointed out. Recently discovered new types of DNA gyrase inhibitors, i.e. tetramic derivatives and biphenyl dicarboxylic acid monoamides, are also briefly mentioned. © 1990.
引用
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页码:1 / 17
页数:17
相关论文
共 195 条
[31]   DNA GYRASE AND THE SUPERCOILING OF DNA [J].
COZZARELLI, NR .
SCIENCE, 1980, 207 (4434) :953-960
[32]   ENANTIOMERS OF 1-ETHYL-7-[3-[(ETHYLAMINO)METHYL]-1-PYRROLIDINYL]-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID - PREPARATION AND BIOLOGICAL-ACTIVITY [J].
CULBERTSON, TP ;
DOMAGALA, JM ;
NICHOLS, JB ;
PRIEBE, S ;
SKEEAN, RW .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (10) :1711-1715
[33]  
CULBERTSON TP, 1989, QUINOLONES, P47
[34]   NEW STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE QUINOLONE ANTIBACTERIALS USING THE TARGET ENZYME - THE DEVELOPMENT AND APPLICATION OF A DNA GYRASE ASSAY [J].
DOMAGALA, JM ;
HANNA, LD ;
HEIFETZ, CL ;
HUTT, MP ;
MICH, TF ;
SANCHEZ, JP ;
SOLOMON, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) :394-404
[35]   1-ETHYL-7-[3-[(ETHYLAMINO)METHYL]-1-PYRROLIDINYL]-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID - A NEW QUINOLONE ANTIBACTERIAL WITH POTENT GRAM-POSITIVE ACTIVITY [J].
DOMAGALA, JM ;
HEIFETZ, CL ;
MICH, TF ;
NICHOLS, JB .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (04) :445-448
[36]   7-SUBSTITUTED 5-AMINO-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NEW CLASS OF QUINOLONE ANTIBACTERIALS [J].
DOMAGALA, JM ;
HAGEN, SE ;
HEIFETZ, CL ;
HUTT, MP ;
MICH, TF ;
SANCHEZ, JP ;
TREHAN, AK .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (03) :503-506
[37]   1-SUBSTITUTED 7-[3-[(ETHYLAMINO)METHYL]-1-PYRROLIDINYL]-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS - NEW QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS AT N1 FOR THE QUINOLONE ANTIBACTERIALS [J].
DOMAGALA, JM ;
HEIFETZ, CL ;
HUTT, MP ;
MICH, TF ;
NICHOLS, JB ;
SOLOMON, M ;
WORTH, DF .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (05) :991-1001
[38]   INHIBITORS OF DNA TOPOISOMERASES [J].
DRLICA, K ;
FRANCO, RJ .
BIOCHEMISTRY, 1988, 27 (07) :2253-2259
[39]   INHIBITORS OF DNA GYRASE [J].
DRLICA, K ;
COUGHLIN, S .
PHARMACOLOGY & THERAPEUTICS, 1989, 44 (01) :107-121
[40]   BIOLOGY OF BACTERIAL DEOXYRIBONUCLEIC-ACID TOPOISOMERASES [J].
DRLICA, K .
MICROBIOLOGICAL REVIEWS, 1984, 48 (04) :273-289