ALTERED MAMMARY RESPONSIVENESS TO ESTRADIOL AND PROGESTERONE IN MICE EXPOSED NEONATALLY TO DIETHYLSTILBESTROL

被引：12

作者：

BERN, HA ^{[1
]}

MILLS, KT ^{[1
]}

HATCH, DL ^{[1
]}

OSTRANDER, PL ^{[1
]}

IGUCHI, T ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,CANC RES LAB,BERKELEY,CA 94720

来源：

CANCER LETTERS | 1992年 / 63卷 / 02期

关键词：

HORMONE SENSITIVITY; BREAST DIETHYLSTILBESTROL (DES); SEX HORMONES; ESTROGEN;

D O I：

10.1016/0304-3835(92)90061-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mammary glands from ovariectomised neonatally diethylstilbestrol (DES)-exposed (0.1-mu-g daily for the first 5 days of life) mice seem morphologically indistinguishable from those of ovariectomised controls. However, administration of exogenous hormones reveals a differential response. In DES-exposed mice, estrogen implantation resulted in greater incidence of dilated ducts along with greater incidence and severity of terminal ductal hyperplasia and greater severity of cystic alveolar adenosis; combined estrogen and progestin treatment resulted in greater severity of terminal duct hyperplasia and less alveolar formation, and progestin treatment resulted in lower incidence and degree of lateral budding. Thus, mammary sensitivity to sex steroids is altered by early exposure of mice to DES.

引用

页码：117 / 124

页数：8

共 29 条

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[12]

LEVAYYOUNG BK, 1989, P SOC EXP BIOL MED, V192, P187, DOI 10.3181/00379727-192-42977

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