SDZ-205,152, A NOVEL DOPAMINE RECEPTOR AGONIST, REDUCES ORAL ETHANOL SELF-ADMINISTRATION IN RATS

被引：53

作者：

RASSNICK, S ^{[1
]}

PULVIRENTI, L ^{[1
]}

KOOB, GF ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT NEUROPHARMACOL, BCR 1, LA JOLLA, CA 92037 USA

来源：

ALCOHOL | 1993年 / 10卷 / 02期

关键词：

ETHANOL; ETHANOL SELF-ADMINISTRATION; DOPAMINE; DOPAMINE AGONIST;

D O I：

10.1016/0741-8329(93)90091-2

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effects of SDZ-205,152, a synthetic mixed D1/D2 dopamine receptor agonist, was investigated in rats trained to orally self-administer ethanol (10% w/v) in a free-choice, two-lever operant task. Pretreatment with SDZ-205,152, at doses of 0.5-5.0 mg/kg subcutaneously 30 min prior to limited access to 10% ethanol and water, selectively reduced ethanol-reinforced responding without affecting responses for water. These results demonstrate that ethanol-reinforced responding was attenuated by SDZ-205,152 and suggests that dopamine neural systems may mediate, in part, the reinforcing properties associated with voluntary ethanol self-administration.

引用

页码：127 / 132

页数：6