DIFFERENTIAL CALBINDIN-LIKE IMMUNOREACTIVITY IN THE BRAIN-STEM AUDITORY-SYSTEM OF THE CHINCHILLA

被引:34
作者
KELLEY, PE
FRISINA, RD
ZETTEL, ML
WALTON, JP
机构
[1] UNIV ROCHESTER,SCH MED & DENT,DEPT PHYSIOL,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,SCH MED & DENT,DEPT SURG,DIV OTOLARYNGOL,ROCHESTER,NY 14642
关键词
HEARING; CALBINDIN; SUPERIOR OLIVE; INFERIOR COLLICULUS; LATERAL LEMNISCUS;
D O I
10.1002/cne.903200205
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Calbindin is a 28 kD calcium-binding protein found in neural tissue. Although its functional role in neurons is unknown, it has been proposed that calbindin is involved in intracellular buffering and could therefore influence temporal precision of neuronal firing. In the barn owl, calbindin-like immunoreactivity was found to be selectively present in brain stem auditory pathways used to process interaural time differences, but was absent from the interaural intensity pathway. The present study demonstrates calbindin immunoreactivity in the auditory brain stem of the chinchilla, a rodent with exceptionally good low-frequency hearing. In the superior olivary complex and periolivary areas, immunoreactivity was divided between neuropil labeling in the lateral and medial superior olives and dorsomedial periolivary nucleus, and labeling of the somata of the medial and ventral nuclei of the trapezoid body and anterolateral periolivary nucleus. Strong immunoreactivity was observed in the ventral and dorsal divisions of the ventral nucleus of lateral lemniscus somata and the vental division's columnarly organized fiber plexus. The dorsal nucleus of the lateral lemniscus was void of immunoreactivity. Virtually all principal neurons of the sagulum showed darkly labeled somata surrounded by a densely labeled fiber plexus. Immunoreactivity in the inferior colliculus was primarily limited to the paracentral nuclei, with only an occasional labeled cell in the central nucleus. In conclusion, although selective labeling of calbindin in the mammalian auditory brain stem is impressive, no distinctive labeling of a functionally defined timing pathway was apparent as reported previously in the barn owl or electric fish.
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收藏
页码:196 / 212
页数:17
相关论文
共 44 条
[1]   CALCIUM-BINDING PROTEIN DISTRIBUTION IN THE RAT-BRAIN [J].
BAIMBRIDGE, KG ;
MILLER, JJ ;
PARKES, CO .
BRAIN RESEARCH, 1982, 239 (02) :519-525
[2]   IMMUNOCYTOCHEMICAL AND LESION STUDIES SUPPORT THE HYPOTHESIS THAT THE PROJECTION FROM THE MEDIAL NUCLEUS OF THE TRAPEZOID BODY TO THE LATERAL SUPERIOR OLIVE IS GLYCINERGIC [J].
BLEDSOE, SC ;
SNEAD, CR ;
HELFERT, RH ;
PRASAD, V ;
WENTHOLD, RJ ;
ALTSCHULER, RA .
BRAIN RESEARCH, 1990, 517 (1-2) :189-194
[3]   LOCATION OF STRUCTURALLY SIMILAR AREAS IN CHINCHILLA COCHLEAS OF DIFFERENT LENGTHS [J].
BOHNE, BA ;
CARR, CD .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1979, 66 (02) :411-414
[4]  
BRAUN K, 1990, ASS RES OT ABSTR, V13, P388
[5]   DISTRIBUTION AND CO-LOCALIZATION OF CALBINDIN D28K WITH VIP AND NEUROPEPTIDE-Y BUT NOT SOMATOSTATIN, GALANIN AND SUBSTANCE-P IN THE ENTERIC NERVOUS-SYSTEM OF THE RAT [J].
BUCHAN, AMJ ;
BAIMBRIDGE, KG .
PEPTIDES, 1988, 9 (02) :333-338
[6]  
BURDICK CK, 1975, J ACOUST SOC AM, V58, P414
[7]   TIME CODING IN ELECTRIC FISH AND BARN OWLS [J].
CARR, CE .
BRAIN BEHAVIOR AND EVOLUTION, 1986, 28 (1-3) :122-133
[8]   CALBINDIN-D-28K AND PARVALBUMIN IN THE RAT NERVOUS-SYSTEM [J].
CELIO, MR .
NEUROSCIENCE, 1990, 35 (02) :375-475
[9]   CALBINDIN IMMUNOREACTIVITY ALTERNATES WITH CYTOCHROME-C-OXIDASE-RICH ZONES IN SOME LAYERS OF THE PRIMATE VISUAL-CORTEX [J].
CELIO, MR ;
SCHARER, L ;
MORRISON, JH ;
NORMAN, AW ;
BLOOM, FE .
NATURE, 1986, 323 (6090) :715-717
[10]   SPONTANEOUS OTOACOUSTIC EMISSIONS IN CHINCHILLA EAR CANALS - CORRELATION WITH HISTOPATHOLOGY AND SUPPRESSION BY EXTERNAL TONES [J].
CLARK, WW ;
KIM, DO ;
ZUREK, PM ;
BOHNE, BA .
HEARING RESEARCH, 1984, 16 (03) :299-314