DOPAMINERGIC STIMULATION UP-REGULATES THE INVIVO EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) IN THE STRIATUM

被引：104

作者：

OKAZAWA, H

MURATA, M

WATANABE, M

KAMEI, M

KANAZAWA, I

机构：

[1] Department of Neurology, Faculty of Medicince, University of Tokyo, Bunkyo-ku, Tokyo, 113

来源：

FEBS LETTERS | 1992年 / 313卷 / 02期

关键词：

BRAIN-DERIVED NEUROTROPHIC FACTOR; DOPAMINE; TRANSCRIPTION; STRIATUM;

D O I：

10.1016/0014-5793(92)81430-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of dopamine on the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum of mouse. BDNF mRNA expression in the striatum, which was quantified with the reverse transcriptase polymerase chain reaction, was up-regulated from 2 h after oral administration of levodopa, a precursor of dopamine. The increase was sustained for 16 h. Co-administration of haloperidol partially inhibited dopamine-induced BDNF enhancement. These data suggest that dopaminergic stimulation directly promotes the expression of BDNF in the striatum in vivo.

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页码：138 / 142

页数：5

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