THE SYNTHESIS OF NOVEL MIMICS OF THE SIALYL-LEWIS-X DETERMINANT

被引：20

作者：

ALLANSON, NM ^{[1
]}

DAVIDSON, AH ^{[1
]}

FLOYD, CD ^{[1
]}

MARTIN, FM ^{[1
]}

机构：

[1] BRITISH BIOTECH PHARMACEUT LTD,DEPT MED CHEM,OXFORD OX4 5LY,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)86284-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Disaccharide mimics of the sialyl Lewis X (sLe(x)) ligands have been prepared as potential antagonists of binding to the lectin domains-of the E-selectin adhesion molecule. Versatile derivatives of sialic acid provide an entry to a series of simplified linker groups supporting the fucose and sialyl residues. The stereoselectivity of nucleophilic addition to the fucosyl ketone derivative 7 is determined by the conditions employed; basic and Lewis acid conditions give opposite results(1).

引用

页码：2061 / 2076

页数：16

共 27 条

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