THE SEQUENCE OF 5' FLANKING DNA FROM THE RAT PREPROTACHYKININ GENE - ANALYSIS OF PUTATIVE TRANSCRIPTION FACTOR BINDING-SITES

被引：6

作者：

CHAPMAN, K ^{[1
]}

LYONS, V ^{[1
]}

HARMAR, AJ ^{[1
]}

机构：

[1] ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT,EDINBURGH,SCOTLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 03期

关键词：

PREPROTACHYKININ GENE; 5' FLANKING SEQUENCE; PUTATIVE TRANSCRIPTION FACTOR BINDING SITE; (RAT);

D O I：

10.1016/0167-4781(93)90233-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rat preprotachykinin A (rPPT-A) gene is expressed in restricted populations of neurons and endocrine cells, including a subset of dorsal root ganglion (DRG) neurons. As part of a study to investigate the DNA sequences responsible for tissue-specific expression of the gene, we have determined the sequence of the 5' flanking DNA to 3350 bp upstream of the transcription start site. The sequenced region encodes a number of putative transcription factor binding sites which may play important roles in the regulation of rPPT-A gene transcription.

引用

页码：361 / 363

页数：3

共 23 条

[1] SEXUALLY DIMORPHIC DISTRIBUTION OF SUBSTANCE-P IN SPECIFIC ANTERIOR-PITUITARY CELL-POPULATIONS
BROWN, ER
ROTH, KA
KRAUSE, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1222 - 1226
[2] CARTER MS, 1990, J NEUROSCI, V10, P2203
[3] CUELLO AC, 1982, CIBA F SYMP, V91, P55
[4] IDENTIFICATION OF NERVE GROWTH FACTOR-RESPONSIVE SEQUENCES WITHIN THE 5' REGION OF THE BOVINE PREPROTACHYKININ GENE
GILCHRIST, CA
MORRISON, CF
CHAPMAN, KE
HARMAR, AJ
[J]. DNA AND CELL BIOLOGY, 1991, 10 (10) : 743 - 749
[5] NERVE GROWTH-FACTOR REGULATES TYROSINE-HYDROXYLASE GENE-TRANSCRIPTION THROUGH A NUCLEOPROTEIN COMPLEX THAT CONTAINS C-FOS
GIZANGGINSBERG, E
ZIFF, EB
[J]. GENES & DEVELOPMENT, 1990, 4 (04) : 477 - 491
[6] EFFECT OF PROTEIN-SYNTHESIS INHIBITORS ON GROWTH-FACTOR ACTIVATION OF C-FOS, C-MYC, AND ACTIN GENE-TRANSCRIPTION
GREENBERG, ME
HERMANOWSKI, AL
ZIFF, EB
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (04) : 1050 - 1057
[7] IDENTIFICATION AND CDNA SEQUENCE OF DELTA PREPROTACHYKININ, A 4TH SPLICING VARIANT OF THE RAT SUBSTANCE-P PRECURSOR
HARMAR, AJ
HYDE, V
CHAPMAN, K
[J]. FEBS LETTERS, 1990, 275 (1-2) : 22 - 24
[8] HARMAR AJ, 1988, ROLE RNA SPLICING PO, P29
[9] KAGEYAMA R, 1991, J BIOL CHEM, V266, P15525
[10] SUBSTANCE P-LIKE IMMUNOREACTIVITY IN ADRENAL CHROMAFFIN CELLS AND INTRA-ADRENAL NERVE-FIBERS OF RATS
KURAMOTO, H
KONDO, H
FUJITA, T
[J]. HISTOCHEMISTRY, 1985, 82 (06) : 507 - 512

← 1 2 3 →