CLONING, CHROMOSOMAL LOCALIZATION AND EXPRESSION PATTERN OF THE POU DOMAIN GENE OCT-11

被引：45

作者：

GOLDSBOROUGH, AS

HEALY, LE

COPELAND, NG

GILBERT, DJ

JENKINS, NA

WILLISON, KR

ASHWORTH, A

机构：

[1] INST CANC RES, CHESTER BEATTY LABS, FULHAM RD, LONDON SW3 6JB, ENGLAND

[2] NCI, FREDERICK CANC RES & DEV CTR, MAMMALIAN GENET LAB, ABL BASIC RES PROGRAM, FREDERICK, MD 21702 USA

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 01期

关键词：

D O I：

10.1093/nar/21.1.127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oct-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene is expressed during mouse embryogenesis and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3/NS-1/1-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene.

引用

页码：127 / 134

页数：8