PROSPECTS FOR XENOGRAFTING

被引：29

作者：

DORLING, A

LECHLER, RI

机构：

[1] Royal Postgraduate Medical School, Hammersmith Hospital, London

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 05期

关键词：

D O I：

10.1016/0952-7915(94)90082-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

New insights into the mechanisms of hyperacute rejection, endothelial cell activation and accommodation are clarifying the processes that determine the rejection of discordant xenografts. Recent advances include the identification of endothelial cell antigens targeted by human anti-pig antibodies and an increasing understanding of the mechanisms underlying endothelial cell activation. Novel ways to prevent hyperacute rejection, including new therapeutic agents and the use of organs from transgenic animals, are promising to significantly improve the early survival of pig organs transplanted into man. Clinical xenotransplantation has become a realizable goal.

引用

收藏

页码：765 / 769

页数：5

相关论文

共 44 条

[1]

BACH FH, 1993, XENO, V1, P8

[2] MONOCLONAL-ANTIBODY TO MURINE PECAM-1 (CD31) BLOCKS ACUTE-INFLAMMATION IN-VIVO [J].

BOGEN, S ;

PAK, J ;

GARIFALLOU, M ;

DENG, XH ;

MULLER, WA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) :1059-1064

[3]

BUSSOLINO F, 1994, J BIOL CHEM, V269, P2877

[4]

CALNE RY, 1970, TRANSPL P, V2, P550

[5] SPECIFIC INTRAVENOUS CARBOHYDRATE THERAPY - A NEW CONCEPT IN INHIBITING ANTIBODY-MEDIATED REJECTION EXPERIENCE WITH ABO-INCOMPATIBLE CARDIAC ALLOGRAFTING IN THE BABOON [J].

COOPER, DKC ;

YE, Y ;

NIEKRASZ, M ;

KEHOE, M ;

MARTIN, M ;

NEETHLING, FA ;

KOSANKE, S ;

DEBAULT, LE ;

WORSLEY, G ;

ZUHDI, N ;

ORIOL, R ;

ROMANO, E .

TRANSPLANTATION, 1993, 56 (04) :769-777

[6]

COOPER DKC, 1991, XENOTRANSPLANTATION, P481

[7] PREVENTION OF COMPLEMENT-MEDIATED ACTIVATION OF XENOGENEIC ENDOTHELIAL-CELLS IN AN IN-VITRO MODEL OF XENOGRAFT HYPERACUTE REJECTION BY C1 INHIBITOR [J].

DALMASSO, AP ;

PLATT, JL .

TRANSPLANTATION, 1993, 56 (05) :1171-1176

[8] CYTOKINE-INDUCIBLE EXPRESSION IN ENDOTHELIAL-CELLS OF AN I-KAPPA-B-ALPHA-LIKE GENE IS REGULATED BY NF-KAPPA-B [J].

DEMARTIN, R ;

VANHOVE, B ;

CHENG, Q ;

HOFER, E ;

CSIZMADIA, V ;

WINKLER, H ;

BACH, FH .

EMBO JOURNAL, 1993, 12 (07) :2773-2779

[9] INTERACTION OF THE NATURAL ANTI-GAL ANTIBODY WITH ALPHA-GALACTOSYL EPITOPES - A MAJOR OBSTACLE FOR XENOTRANSPLANTATION IN HUMANS [J].

GALILI, U .

IMMUNOLOGY TODAY, 1993, 14 (10) :480-482

[10] EVIDENCE THAT POLYREACTIVE ANTIBODIES ARE DEPOSITED IN REJECTED DISCORDANT XENOGRAFTS [J].

GELLER, RL ;

BACH, FH ;

TURMAN, MA ;

CASALI, P ;

PLATT, JL .

TRANSPLANTATION, 1993, 55 (01) :168-172

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