A HOMEOTIC GENE-CLUSTER PATTERNS THE ANTEROPOSTERIOR BODY AXIS OF C-ELEGANS

被引：282

作者：

WANG, BB ^{[1
]}

MULLERIMMERGLUCK, MM ^{[1
]}

AUSTIN, J ^{[1
]}

ROBINSON, NT ^{[1
]}

CHISHOLM, A ^{[1
]}

KENYON, C ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

CELL | 1993年 / 74卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(93)90292-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In insects and vertebrates, clusters of Antennapedia class homeobox (HOM-C) genes specify anteroposterior body pattern. The nematode C. elegans also contains a small cluster of HOM-C genes, one of which has been shown to specify positional identity. Here we show that two additional C. elegans HOM-C genes also specify positional identity and that together these three HOM-C genes function along the anteroposterior axis in the same order as their homologs in other organisms. Thus, HOM-C-based pattern formation has been conserved in nematodes despite the many differences in morphology and embryology that distinguish them from other phyla. Each C. elegans HOM-C gene is responsible for a distinct body region; however, where their domains overlap, two HOM-C genes can act together to specify the fates of individual cells.

引用

页码：29 / 42

页数：14

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