CONJUGATES OF DENDRITIC CELLS AND MEMORY T-LYMPHOCYTES FROM SKIN FACILITATE PRODUCTIVE INFECTION WITH HIV-1

被引:460
作者
POPE, M
BETJES, MGH
ROMANI, N
HIRMAND, H
CAMERON, PU
HOFFMAN, L
GEZELTER, S
SCHULER, G
STEINMAN, RM
机构
[1] VRIJE UNIV AMSTERDAM, DEPT CELL BIOL, 1081 BT AMSTERDAM, NETHERLANDS
[2] CORNELL UNIV, COLL MED, DIV PLAST SURG, NEW YORK, NY 10021 USA
[3] UNIV INNSBRUCK, DEPT DERMATOL, A-6020 INNSBRUCK, AUSTRIA
关键词
D O I
10.1016/0092-8674(94)90418-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Experimentally, a productive infection with HIV-1 requires that virus be administered to T cells that are activated by mitogens. We describe a productive milieu for HIV-1 within the confines of normal skin that does not require standard stimuli. The milieu consists of dendritic cells and T cells that emigrate from skin and produce distinctive stable, nonproliferating conjugates. These conjugates, upon exposure to each of seven different HIV-1 isolates, begin to release high levels of virus progeny within 4 days. Numerous infected syncytia, comprised of both dendritic and T cells, rapidly develop. We propose that conjugates of dendritic cells and T cells, as found in the external linings of organs involved in sexual transmission of HIV-1, represent an important site for the productive phase of HIV-1 infection. Because the affected T cells carry the memory phenotype, this site additionally provides a mechanism for the chronic depletion of CD4(+) memory cells in HIV-1 disease.
引用
收藏
页码:389 / 398
页数:10
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