AMINO-ACIDS AND PEPTIDES .9. SOME NEIGHBOURING-GROUP AMINO-AMIDE AND HYDROXY-AMIDE INTERACTIONS

被引：25

作者：

DAVIES, JA

HASSALL, CH

ROGERS, IH

机构：

[1] Department of Chemistry, University College of Swansea, Swansea

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 10期

关键词：

D O I：

10.1039/j39690001358

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base-catalysed hydrolysis studies have provided evidence of neighbouring-group amino-amide interactions in compounds with the formulae H2N·[CH2]χ·CO·NHMe (x = 3, 4, or 5), and in 6-aminodecane-10-lactam. Acid-catalysed hydrolysis studies have indicated that transannular hydroxy-amide interactions occur with 4-hydroxy-hexane-6-lactam, 5-hydroxyoctane-8-lactam, and 6-hydroxydecane-10- lactam. The mechanisms of these reactions and the significance of such processes in peptide chemistry is discussed.

引用

页码：1358 / &

共 39 条

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