ANALYSIS OF DRUGS IN THE PRESENCE OF SERUM-ALBUMIN BY LIQUID-CHROMATOGRAPHY WITH ELUENTS CONTAINING SURFACTANTS

被引：24

作者：

GROHS, RA ^{[1
]}

WARREN, FV ^{[1
]}

BIDLINGMEYER, BA ^{[1
]}

机构：

[1] MILLIPORE CORP,DIV WATERS CHROMATOG,34 MAPLE ST,MILFORD,MA 01757

来源：

ANALYTICAL CHEMISTRY | 1991年 / 63卷 / 04期

关键词：

D O I：

10.1021/ac00004a016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Surfactant-containing eluents are evaluated for possible application to direct serum injection using conventional reverse-phase columns. Serum albumin was quantitatively eluted at the column void volume by using surfactant concentrations below or above the critical micelle concentration, and organic solvents could be used in proportions as high as 40% (w/w). Surfactant choice, pH, and salt effects were also evaluated.

引用

页码：384 / 390

页数：7

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