EXPRESSION OF THE PS2 PEPTIDE IN PRIMARY BREAST CARCINOMAS - COMPARISON OF MEMBRANE AND CYTOPLASMIC STAINING PATTERNS

被引:13
作者
DOOKERAN, KA [1 ]
RYE, PD [1 ]
DEARING, SJ [1 ]
WALKER, RA [1 ]
机构
[1] UNIV LEICESTER,GLENFIELD GEN HOSP,BREAST CANC RES UNIT,GROBY RD,LEICESTER LE3 9QP,ENGLAND
关键词
BREAST CANCER; PS2; IMMUNOHISTOCHEMISTRY; ESTROGEN RECEPTOR;
D O I
10.1002/path.1711710209
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The pS2 protein is oestrogen-regulated in breast cancer cell lines. Previous studies have shown a relationship to oestrogen receptor in primary breast carcinomas. This study examined 178 breast carcinomas for pS2 using immunohistochemistry. A high frequency (77 per cent) of positive tumours was found, using a 10 per cent cut-off point to define a positive tumour. There was no relationship with menopausal status or node status, a significant association with differentiation, a weak association with oestrogen receptor, and no association with progesterone receptor or overall survival. Two patterns of cellular localization were observed: cytoplasmic and membrane. The former showed a stronger relationship with oestrogen receptor status, although there were oestrogen receptor-negative tumours with marked pS2 staining. Membrane staining showed a stronger relationship with differentiation, with a staining pattern similar to that observed for milk fat globule membrane. The staining patterns observed may support a role for pS2 in a secretory mechanism. However, the expression and function of pS2 in breast carcinomas remain complex, and are not simply related to oestrogen regulation.
引用
收藏
页码:123 / 129
页数:7
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