OXYTOCIN NEURONS IN THE RAT HYPOTHALAMUS EXHIBIT C-FOS IMMUNOREACTIVITY UPON OSMOTIC-STRESS

被引：110

作者：

GIOVANNELLI, L ^{[1
]}

SHIROMANI, PJ ^{[1
]}

JIRIKOWSKI, GF ^{[1
]}

BLOOM, FE ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093

来源：

BRAIN RESEARCH | 1990年 / 531卷 / 1-2期

关键词：

C-fos; Hypothalamus; Osmotic stress; Oxytocin; Paraventricular nucleus; Supraoptic nucleus; Transcription activation;

D O I：

10.1016/0006-8993(90)90789-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to evaluate the responses to osmotic stress of oxytocinergic neurons in vivo, we have studied oxytocin (OXY) and c-fos protein expression in the brain by means of double-immunostaining. C-fos immunoreactivity was detected in a subset of OXY neurons, as well as in other neurons non-immunoreactive for OXY, as early as 90 min after intraperitoneal injection of a hypertonic saline solution. C-fos expression was found in approx. 70% of OXY-immunoreactive neurons in the supraoptic (SON), lateral subcommisural (LSN) and paraventricular (PVN) nuclei, and not in OXY neurons in other hypothalamic areas. The expression of c-fos may be used as a means to map the circuitry by which osmotic stimulation activates OXY-containing neurons, and thus provide further insights into the functions with which OXY may be associated. © 1990.

引用

页码：299 / 303

页数：5

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