MORPHINE HYPERALGESIC EFFECTS ON THE FORMALIN TEST IN DOMESTIC-FOWL (GALLUS-GALLUS)

被引:34
作者
HUGHES, RA
SUFKA, KJ
机构
[1] Iowa State University, Ames
关键词
HYPERALGESIA; MORPHINE; NALOXONE; FORMALIN TEST; OPIATE; OPIOID; CHICKEN; PAIN; NOCICEPTION; NARCOTIC DRUGS; NARCOTIC ANTAGONISTS;
D O I
10.1016/0091-3057(91)90273-5
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Preliminary research demonstrated that formalin injected into the foot of leghorn cockerels elicited significantly more footlifts of longer duration than physiological saline. The formalin test was subsequently used to examine morphine effects in this species. Previous research demonstrated strain-dependent naloxone-reversible morphine hyperalgesia against thermal nociception in cockerels. In Experiment 1 herein White Leghorn cockerels were given either 0.0, 0.5, 1.5, or 2.5% formalin SC into the foot 30 min after an IM injection of either physiological saline or 2.5 mg/kg morphine sulfate. The frequency and duration of formalin-elicited footlifts increased significantly as a function of formalin concentration. Morphine significantly increased footlift frequency and duration at all but the 0.0% formalin concentration. Morphine inhibited respiration in these animals. In Experiment 2, naloxone (5.0 mg/kg) significantly reversed both the hyperalgesia and the respiratory depression induced by morphine. These results demonstrate that morphine hyperalgesia in leghorn cockerels is neither unique to hot plate test procedures nor peculiar to thermal nociception. Atypical morphine effects in this model may be specific to nociception, however, because hyperalgesia was not accompanied by atypical morphine effects on respiration.
引用
收藏
页码:247 / 251
页数:5
相关论文
共 20 条
[1]   MORPHINE ANALGESIA IN THE TAIL-FLICK AND FORMALIN PAIN TESTS IS MEDIATED BY DIFFERENT NEURAL SYSTEMS [J].
ABBOTT, FV ;
MELZACK, R ;
SAMUEL, C .
EXPERIMENTAL NEUROLOGY, 1982, 75 (03) :644-651
[2]   A DOSE-RATIO COMPARISON OF MU-AGONISTS AND KAPPA-AGONISTS IN FORMALIN AND THERMAL PAIN [J].
ABBOTT, FV ;
FRANKLIN, KBJ ;
LIBMAN, RB .
LIFE SCIENCES, 1986, 39 (21) :2017-2024
[3]   FORMALIN TEST - QUANTITATIVE STUDY OF ANALGESIC EFFECTS OF MORPHINE, MEPERIDINE, AND BRAIN-STEM STIMULATION IN RATS AND CATS [J].
DUBUISSON, D ;
DENNIS, SG .
PAIN, 1977, 4 (02) :161-174
[4]   ANIMAL HYPNOSIS - FACTUAL STATUS OF A FICTIONAL CONCEPT [J].
GALLUP, GG .
PSYCHOLOGICAL BULLETIN, 1974, 81 (11) :836-853
[5]   NALOXONE-SENSITIVE HYPERALGESIA FOLLOWS ANALGESIA INDUCED BY MORPHINE AND ENVIRONMENTAL STIMULATION [J].
HENDRIE, CA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (04) :961-966
[6]   SHOCK-POTENTIATED TONIC IMMOBILITY IN CHICKENS AS A FUNCTION OF POST-HATCH AGE [J].
HUGHES, RA .
ANIMAL BEHAVIOUR, 1979, 27 (AUG) :782-785
[7]   STRAIN-DEPENDENT MORPHINE-INDUCED ANALGESIC AND HYPERALGESIC EFFECTS ON THERMAL NOCICEPTION IN DOMESTIC-FOWL (GALLUS-GALLUS) [J].
HUGHES, RA .
BEHAVIORAL NEUROSCIENCE, 1990, 104 (04) :619-624
[8]   CODEINE ANALGESIC AND MORPHINE HYPERALGESIC EFFECTS ON THERMAL NOCICEPTION IN DOMESTIC-FOWL [J].
HUGHES, RA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (03) :567-570
[9]  
Jaffe J. H, 1985, PHARMACOL BASIS THER, P491
[10]  
KAYAN S, 1971, J PHARMACOL EXP THER, V177, P509