SUPRAMOLECULAR CHEMISTRY .37. AMINOCYCLODEXTRINS AS SELECTIVE HOSTS WITH SEVERAL BINDING-SITES FOR NUCLEOTIDES

A simultaneous discrimination between 3′‐ and 5′‐phosphates, 2′‐oxy‐ and 2′‐deoxyriboses and nucleobases of nucleotides is made possible by the use of β‐cyclodextrins with ammonio substituents in the 6 position; the corresponding host–guest complex (shown schematically) forms in water in the process. NMR spectroscopic investigations show that the sugar unit is found inside the cyclodextrin cavity. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany